TABLE 1.Electrophysiological parameters for SP neurons and FS interneurons from mature cortex-striatum-substantia nigra cultures
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Response Parameter | SP Neuron | FS Interneuron |
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Number of cells | 92 | 48 |
Resting membrane potential, mV | –78.6 ± 0.38 | –61.8 ± 1.10† |
Input resistance MΩ | 338 ± 18 | 313 ± 52† |
Time constant ms | 10.9 ± 0.72 | 8.3 ± 0.90* |
AP threshold, mV | –27.0 ± 0.6 | –26.9 ± 0.9 |
AP amplitude, mV | 70.2 ± 0.9 | 60.4 ± 1.5† |
AP width, ms | 1.12 ± 0.04 | 0.65 ± 0.05† |
AHP amplitude, mV | 14.3 ± 0.5 | 20.3 ± 0.8† |
AHP time, ms | 12.3 ± 0.5 | 4.1 ± 0.55† |
Values are mean ± SE.
* P < 0.05;
† P < 0.005. SP, spiny projection; FS, fast spiking; AP, action potential; AHP, afterhyperpolarization.